Seraphine Runes: Which Ones to Use
Sorcery runes seem to work best as Seraphine's primary. Among the sorcery runes, players are finding success with Summon Aery. Manaflow Band, Transcendence, and Scorch should fill out the rest of your page. Summon Aery is a classic for Enchanters like Seraphine, letting them up to their harassment or support with a reliable way of hitting and buffing. Aery will trigger multiple times during the duration of her abilities.
Unlike Arcane Comet, Aery can't miss. It just comes at the cost of lower damage and worse level scaling, but the consistency it grants is a powerful tool.
The secondary should be Inspiration. Fill this one out with Biscuit Delivery, Cosmic Insight and grab the Adaptive Force and Magic Resist charms.
If you're using Inspiration as the primary, use Glacial Augment with Magical Footwear, Biscuit Delivery and Approach Velocity. The secondary Sorcery runes should still be Manaflow Band and Transcendence. Use the same Adaptive Force charms, but pick up some armor instead of Magic Resist.